Hi everyone,

 

I thought you might be interested in some initial data we have been able to generate due to the support of the HCL Research Foundation.

 

Attached are three photographs of tumors that we produced in mice by injection of human hairy cell leukemia cells.

 

DSCF0560.JPG  is the tumor that developed when we did a control manipulation to the cells (stably transfected with an empty plasmid vector).

 

DSCF0611.JPG and DSCF0627.JPG are tumors that developed when we reconstituted appropriate expression of a gene that we have found is expressed at abnormally low levels in HCL (stably transfected with a plasmid vector producing RhoH).

 

As you can see when we put in RhoH the tumors are very much smaller!

 

We are now going to repeat this experiment several more times to determine significance before publication.

 

I would be grateful for your comments and suggestions.

 

Best wishes,

 Simon